McGill University, Canada
Dana-Farber Cancer Institute, Harvard medical School
My laboratory studies the mechanism by which oncogenic Ras induces tumors. Expression of oncogenic Ras in cells induces chromatin changes and cuases tumor development. Gross changes in chromatin can be induced within one cell cycle after expression of oncogenic Ras. We hypothesize that oncogenic Ras induces tumors through its effect on chromatin. We study the chromatin changes and the Ras signaling pathways leading to the changes.
Chen, D.H., Chen, C.T., Zhang, Y., Liu, M.A., Campos-Gonzalez, R., and Pan, B.T. Characterization of p96: immunoreaction with an anti-Erk peptide antibody and activity in Xenopus oocytes and eggs. Biochem. J. 335:43-50, 1998.
Pan, B.-T., Zhang, Y., Brott, B., and D.-H. Chen. The 96kDa protein kinase activated by oncogenic Ras in Xenopus egg extracts is also activated by constitutively active Mek: activation requires serine/threonine phosphorylation. Oncogene 14, 1653-1660, 1997.
Office: (859) 257-5447
Fax: (859) 257-8994
Lab: (859) 257-5447